Building on its autologous CD19 CAR-T cell therapy obe-cel, Autolus added a CD22 CAR to create AUTO1/22. The dual mechanism is intended to address a major cause of treatment failure. Thursday ...

In BrdU incorporation assays cells were stained with mAbs for B220 and CD19, then fixed, permeabilized, treated with DNase. Subsequently, cells were stained with anti-BrdU-FITC mAb according to the ...

CD19 + 成熟 B 细胞增多，这一系列变化都表明重归自然促进了 B 细胞的成熟。在骨髓中，虽然 B 细胞比例有所下降，但 B220 hi IgM + 循环成熟 B 细胞数量和其与未成熟 B 细胞的比例均增加，进一步证实了 B 细胞成熟的加速。 生发中心（GC）反应增强：在对脾脏和 ...

Recently, we reported that deep B cell depletion using a single infusion with autologous CD19 chimeric antigen receptor (CAR) T cells induced drug-free clinical remission in severe SLE patients with ...

这项研究成功建立了一种无基质细胞的 1% BSA X-VIVO15 体外培养系统，该系统仅添加 IL-7 就能促进 CLP 向 B 细胞分化，三种细胞因子联合使用时，能更高效地产生 CD19 + B220 + 和 IgM + CD19 + B220 + 细胞。该系统克服了 OP9 培养系统的诸多缺点，简化了实验流程，降低了 ...

CD19-targeted chimeric antigen receptor (CAR) T-cell therapy has achieved marvelous results in the treatment of patients with relapsed and/or refractory B-cell lymphomas, B-cell acute lymphoblastic ...

lgM-deficiency leads to reduced airway hyperresponsiveness and class switching to IgE in HDM-induced asthma. a Schematic diagram showing sensitisation and challenge protocol where mice (IgM-/-) and ...

B细胞不仅通过表达特异性抗原受体（BCR）发挥免疫效应，还作为抗原提呈细胞参与免疫调节。常用的B细胞标记物包括CD19、CD20和CD45R（B220）。未成熟B细胞表达CD19、CD20、CD34、CD38和CD45R，但不表达IgM；成熟B细胞则主要通过IgM和CD19标识。活化B细胞表达CD30 ...

Despite the mechanisms of central and peripheral tolerance, the mature B cell compartment contains cells reactive for self-antigen. How these cells are poised not to respond and the mechanisms that ...

Impressive results have been achieved by adoptively transferring T-cells expressing CD19-specific CARs with binding domains from murine mAbs to treat B-cell malignancies. T-cell mediated immune ...