Silent synapses are dormant neural connections that hold untapped brain potential. Discover how ketamine, exercise, and other ...

Moreover, it has been reported that higher brain BDNF expression is associated with slower cognitive decline in older adults.

Brain-derived neurotrophic factor (BDNF) has an important role in supporting neuronal survival, which has encouraged studies of its therapeutic potential for neurodegenerative disorders such as ...

This study provides a potentially useful investigation into the positive role of BDNF/TrkB signaling in implanted dental pulp stem cells to enhance dentin regeneration in the context of dental caries.

However, in aged mice, a deficiency of adipose 11β-HSD1 leads to insensitivity to steroid hormones, which in turn decreases the expression of adipose CX3CL1 and subsequently reduces brain BDNF ...

In young mice, the adipose-to-brain crosstalk helps sustain cognitive health by ensuring adequate BDNF production. However, ...

Physical activity enhances DNA demethylation in the promoter region of the Bdnf gene, increasing the expression of the neurogenesis-boosting signaling factor. Moreover, histone acetylation appears to ...

Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer's disease.