Frontiers23 天
Firmicutes Levels in the Mouth Reflect the Gut Condition With Respect to Obesity and Early ...
Changes occurring in the gut microbiota, such as an increase in Firmicutes and a decrease in Bacteroidetes, have been reported to play a pivotal role in the pathogenesis of obesity (Gallardo-Becerra ...
澎湃新闻29 天
Cell子刊：高平/张华凤团队揭示肠道细菌胆汁酸代谢与抗肿瘤免疫的关联
从机制上来说，AKR1D1 的缺失导致一种肠道细菌卵形拟杆菌（Bacteroidetes ovatus）的比例增加，其将鹅去氧胆酸（CDCA）分解为异石胆酸（iso-LCA）。累积的异石胆酸以磷酸化的 CREB1（p-CREB1）依赖的方式损害肝脏 NK 细胞的抗肿瘤活性。 研究团队进一步发现，保钾利尿 ...