Lyme disease, a disease transmitted when deer ticks feed on infected animals like deer and rodents, and then bite humans, impacts nearly half a million individuals in the U.S. annually.

Piperacillin, an antibiotic in the same class as penicillin, effectively cured mice of Lyme disease at 100-times less than the effective dose of doxycycline, the current gold standard treatment. At ...

Iterum Therapeutics plc (Nasdaq: ITRM), a company focused on delivering next generation oral and IV antibiotics to treat infections caused by multi-drug resistant pathogens in both community and ...

Clavulanic acid is a beta-lactam drug that prevents bacteria from destroying other antibiotics. It does this by binding to the active site of beta-lactamases, which are enzymes that break down ...

In most of the patients with low levels of antibiotic in the urine, the organism cultured was klebsiella-enterobacter, and β-lactamase activity was demonstrated in the same urines. From the ...

We demonstrate the effectiveness of DyNoPy on SHV-1 and PDC-3, chromosomally encoded β-lactamases linked to antibiotic resistance, highlighting its potential to inform drug design and address pressing ...

We demonstrate the effectiveness of DyNoPy on SHV-1 and PDC-3, chromosomally encoded β-lactamases linked to antibiotic resistance, highlighting its potential to inform drug design and address pressing ...

“The new antibiotic is a fantastic event ... commonly called ESBL (extended spectrum beta-lactamase) or MDR (multidrug resistant) strains, says Comiter. “This approval will also help patients ...

Diabetes has been associated with elevated risk for or poor therapy of infections by antibiotic-resistant ... extended spectrum β-lactamase-producing Gram-negative bacteria, multidrug-resistant ...

Jacinda Abdul-Mutakabbir, PharmD, MPH, and her colleagues were looking at a study on multidrug-resistant extended-spectrum beta-lactamases (ESBLs), and how rapid diagnostic tools could be influential ...

We summarized pharmaceutical, pharmacokinetic, and pharmacodynamic research on the definition, underlying mechanisms, and risk factors of ARC to guide individualized dosing of antibiotics and various ...