Once cleaved, ROCK-I is constitutively active and is responsible for bleb formation in apoptotic ... it is thought that caspases turn off cell survival and turn on cell disassembly.

Various nuclear shape abnormalities such as micronuclei and nuclear blebs both close to the main nucleus. Nuclear shape abnormalities can lead to a severe impact on genomic DNA integrity.

In 2007, Ho Man “Holly” Tang took a break from her undergraduate biology studies at Iowa ... attack structural proteins composing the cell’s organelles, and dismantle the cytoskeleton, leading cells ...