Cyclin D1–CDK4/6 phosphorylates GTSE1 in cancer cells, preventing its degradation and sustaining high levels across the cell cycle, which enhances proliferation and correlates with poor prognosis.

Feb. 7, 2025 — A research team has made a major discovery on how the CUL5 gene affects CAR-T cell therapy, an advanced cancer therapy. The study reveals that reducing the activity of the CUL5 ...

Investigators released hundreds of images from inside and around Gene Hackman and Betsy Arakawa Hackman's Santa Fe estate as part of evidence released by New Mexico authorities. Gene and Betsy's ...

Nanoscope Therapeutics is on the brink of filing for FDA approval of what could be the first gene therapy for incurable eye disease retinitis pigmentosa (RP) that can be used regardless of ...

Apr. 18, 2025 — A new study provides solutions to the pressing need to identify factors that influence Alzheimer's disease (AD) risk or resistance while providing an ... Key Enzyme in Lipid ...

University of Rome Tor Vergata, Rome, Italy.

A batch of letters and notes gives a glimpse into the lives of Gene Hackman and Betsy Arakawa, which have been released as part of the investigation into their tragic deaths earlier this year ...

We identify aberrant copy number regions including SOX2 (3q26.33), FGFR (8p11.23), CCND1 (11q13.3), CDKN2A/2B (9p21.3), and MYC (8q24.21). HPV status combined with highly mutated genes as predictive ...

In another sign of the challenges facing gene therapy developers, Pfizer has abandoned its haemophilia B treatment Beqvez in all world markets, saying weak demand made the business non-viable.

The large estate that the late Gene Hackman and wife Betsy Arakawa called home in the Santa Fe area could be worth millions if it hits the market. The 12-acre property is located northeast of ...