编辑推荐：针对骨缺损修复中炎症微环境失调、血管化不足和修复材料缺陷三大难题，上海公共卫生临床中心团队开发了具有核壳结构的TCP-PDA-QK纳米复合水凝胶（TPQGel）。该材料通过pH响应释放QK肽和Ca 2+ /PO 4 3-，协同调控PI3K-AKT通路促进M2型巨噬细胞极化，实现 ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Neoantigen vaccine is a promising breakthrough ...

这些基因之前也被发现在由Melanie Greter团队描述的脑边界相关巨噬细胞（BAMs，即CD45+CD11b+Ly6c-CD206+脑巨噬细胞）中显著表达。进一步的基因表达分析和 ...

实验结果表明，hCD40OST小鼠B细胞表型和数量与野生型小鼠一致，并能正常活化；更进一步的研究发现，应用抗hCD40抗体后，hCD40OST小鼠的B细胞表达CD86 ...

VASP 敲低抑制 LPS 诱导的 ALI 小鼠 AMs 的 M1 极化：对 ALI 小鼠 BALF 进行流式细胞术分析，发现 VASP 敲低显著降低了 CD86 + CD206-巨噬细胞的比例，同时增加了 CD206 + CD86 巨噬细胞的比例。免疫荧光染色也证实，VASP 敲低减少了肺组织中 M1 巨噬细胞标记物 CD86 的表达 ...

(A) Distribution of the CD11b + immune cells in group analyzed using t-SNE. (B) Heatmap showing the expression levels of markers in the CD11b + cells. (C) Scatter dot plots showing the frequencies of ...

24-well transwell chamber was bought from Corning (Corning, Shenzhen, China). All flow cytometric antibodies, including F4/80, CD11b, CD86, CD206, CD4, IL4, and Foxp3 were purchased from eBioscience ...

Homogenized intestinal tissues were passed through a 40-μm nylon mesh to get a single-cell suspension. Cells were stained with F4/80, CD11b and CD86, CD11c and CD206 antibodies (eBioscience, San Diego ...