Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. The globo-series glycosphingolipids (GSLs) are unique glycolipids exclusively ...

School of Biomolecular and Biomedical Sciences and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4 D04 V1W8, Ireland ...

Transcriptomic analyses revealed heightened activation of memory CD4 and CD8 T cells, increased cytolytic activity ... A total of 47 immune checkpoint genes were selected for this analysis, including ...

在免疫系统中，免疫耐受的失衡是过敏性哮喘的关键致病因素。不同类型的细胞参与维持免疫耐受，其中 CD4? CD44?记忆 T 细胞与免疫耐受关系密切，而组织驻留记忆 T（TRM）细胞又是 CD4? CD44?记忆 T 细胞的重要亚型。不过，TRM 细胞在哮喘免疫耐受中的作用以及其受 ...

Institute of Immunity and Transplantation, Division of Infection and Immunity, UCL, Royal Free Hospital, London, United Kingdom Department of Pathology and Cell Biology, Columbia University Irving ...

Mononuclear cells were prepared by using Ficoll (Cytiva, USA) gradient centrifugation, stained with Fixable Viability Stain 700 (BD Biosciences, USA) and fluorochrome-conjugated antibodies CD3-APC-Cy7 ...

Objective We aimed to investigate the role of GPR171 in modulating CD4 + T cell effector functions in IBD and evaluate its therapeutic potential. Conclusions GPR171 deficiency promotes Th17 cell ...