在免疫系统中，免疫耐受的失衡是过敏性哮喘的关键致病因素。不同类型的细胞参与维持免疫耐受，其中 CD4? CD44?记忆 T 细胞与免疫耐受关系密切，而组织驻留记忆 T（TRM）细胞又是 CD4? CD44?记忆 T 细胞的重要亚型。不过，TRM 细胞在哮喘免疫耐受中的作用以及其受 ...

Institute of Medical Microbiology and Hygiene and Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg-University, Mainz 55131, Germany Institute of Infection ...

(H) SBP and UACR of pregnant mice injected with PBS, Sham mouse-derived or RUPP mouse-derived CD4 + CD44 + T cells. Data were compared between groups using one-way ANOVA and represented as mean±SEM ...

Researchers investigating the role of the protein CD44 in obesity and metabolic health found that CD44-deficient mice stayed lean even on a high-fat diet, while the control mice developed obesity.

BMP4 (PeproTech) was administrated in 25 ng/µL for footpad injection in 10 µL. BMP4 neutralizing antibody (R&D system) was used in 10mg/kg for i.p. Naïve mouse (CD4+CD62L+CD44−) T cells were purified ...

Immunophenotyping of T cell populations included the identification of naïve (CD3+CD44–CD62L+), memory (CD3+CD44+CD62L+), and effector (CD3+CD44+CD62L−) T cells [CD4+ and CD8+ naïve T cells ...