Background: Circular RNAs (circRNAs) have been recently proposed as hub molecules in various diseases, especially in tumours. We found that circRNAs derived from ribonuclease P RNA component H1 (RPPH1 ...

miR-379-5p 抑制顺铂诱导的 CSC 扩张：在体外实验中，过表达 miR-379-5p 可有效减少顺铂处理后卵巢癌细胞系（SKOV3 和 OVCAR3）中 CSCs（CD44 + CD117 + 细胞）的比例。在体内异种移植模型中，过表达 miR-379-5p 的肿瘤异种移植物在顺铂治疗后，肿瘤体积明显缩小，生长受到 ...

Researchers investigating the role of the protein CD44 in obesity and metabolic health found that CD44-deficient mice stayed lean even on a high-fat diet, while the control mice developed obesity.

Ex-captain Sana Mir criticises the squad selection, saying it was flawed from the start. Their pace attack appeared rusty and part-time spinners were ineffective. Mir calls for a complete overhaul ...

为解决急性肾损伤（AKI）机制不明及治疗策略缺乏的问题，南方医科大学研究人员探究 CD44 在 AKI 中的作用。结果发现 CD44 可加重 AKI，抑制它或成治疗新策略。推荐科研读者阅读，以了解 AKI 新机制与潜在疗法。 在当今社会，急性肾损伤（AKI）就像一个隐藏在 ...

细胞增殖的周期性是生物的一个基础特征。同样适应性免疫的抗原特异性T和B细胞通过克隆扩增产生大量短寿命的效应细胞和一些长寿命的记忆细胞。T细胞主要有两个亚群：辅助性CD4T细胞和细胞毒性CD8T细胞；随着时间推移，记忆性CD4+T和CD8+T通过细胞死亡、存活 ...

Lymphocytes (CD4 T, CD8 T, and regulatory T cells), monocytes, and neutrophils were analyzed by using anti-CD45, anti-CD4, anti-CD8, anti-CD11b, anti-CD44, anti-CD62L, anti-CD279 ... Figure 5 ...

Heterogeneity of lymphatic vessels during embryogenesis is critical for organ-specific lymphatic function. Little is known about lymphatics in the developing kidney, despite their established roles in ...

In order to grow, cancer cells shut down or over-activate genes that normally maintain a cell’s health. The Sonic Hedgehog gene – named after a Japanese cartoon character – is associated with the ...