该研究成功构建了能够表达人源CD40分子（hCD40）的基因敲除小鼠模型（hCD40OST）。实验结果表明，hCD40OST小鼠B细胞表型和数量与野生型小鼠一致，并能正常活化；更进一步的研究发现，应用抗hCD40抗体后，hCD40OST小鼠的B细胞表 ...

There is a general consensus that human MSCs do not express the haematopoietic markers CD45, CD34 and CD14 or the co-stimulatory molecules CD80, CD86 and CD40, whereas they do express variable ...

食管鳞状细胞癌（ESCC）是一种常见的消化道恶性肿瘤，具有侵袭性强、预后差等特点。传统治疗方法（手术、放疗、化疗）的效果有限，总体生存率仍不令人满意。近年来，免疫检查点抑制剂（ICI）在多种癌症中展现出显著疗效，成为治疗领域的一大突破。但由于不同患者对ICI反应存在较大差异，部分患者可获得长期生存，而另一部分则收效甚微。因此，寻找可靠的预测性生物标志物，以指导患者选择和优化治疗方案，尤为关键。

编辑推荐：肿瘤相关巨噬细胞 (TAMs)的极化状态深刻影响肿瘤进展，但其分子调控机制尚不明确。西班牙CIC bioGUNE团队发现，促炎因子IFNγ特异性诱导Syndecan-3 (SDC3)在巨噬细胞表面表达，基因敲除实验证实SDC3通过增强促炎因子分泌、促进T细胞活化及抑制血管生成，赋予巨噬细胞抗肿瘤表型。该研究为靶向TAMs的免疫治疗提供了新策略，发表于《Cellular and ...

Significantly, SAg-exposure enhanced inflammatory activation of CLL tumour cells, which acquired CD38, CD40, CD86, while downregulating CD27 (p≤0.005), even in cultures from ibrutinib-treated CLL ...

Methods Plasmacytoid DCs (pDCs), myeloid DCs (mDCs) and monocytes from patients with SLE, healthy volunteers and healthy volunteers immunised with tetanus/diphtheria were examined by flow cytometry ...

近日，中国科学技术大学生物医学工程学院王育才教授课题组通过体内筛选优化得到的低免疫原性LNPs，成功在体内直接编程生成耐受性抗原呈递细胞（tol-APCs），治疗自身免疫性疾病（AIDs）。相关研究成果以“Generation of tolerogenic antigen-presenting cells in vivo via the delivery of mRNA encoding PDL1 ...

Type 1 diabetes (T1D) is characterized by the autoimmune destruction of insulin-producing β cells within pancreatic islets, the specialized endocrine cell clusters of the pancreas. Islet ...

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