该研究成功构建了能够表达人源CD40分子（hCD40）的基因敲除小鼠模型（hCD40OST）。实验结果表明，hCD40OST小鼠B细胞表型和数量与野生型小鼠一致，并能正常活化；更进一步的研究发现，应用抗hCD40抗体后，hCD40OST小鼠的B细胞表 ...

1 Division of Infectious Diseases, Department of Pediatrics, Washington School of Medicine in St. Louis, St. Louis, MO, United States 2 Division of Immunobiology, Department of Pathology and ...

The immune cells crosstalk with each other at the maternal-fetal interface elaborately. For example, the interaction between B2 cells and Th cells depends on CD40 and its ligand CD40L, which helps B2 ...

PK11195 (ab109497) was purchased from Abcam (Cambridge, United Kingdom). Fluorochrome-conjugated antibodies against mouse CD45, CD11b, Ly6G, Ly6C, F4/80, TNF-a, CD86, MHC II, CD40, CC chemokine ...