Fast Track designation highlights potential of INX-315 to address unmet need for patients with recurrent advanced/metastatic ...

Jakafi ® (ruxolitinib) net product revenues of $709 million in Q1'25 (+24% Y/Y); increasing full year 2025 Jakafi guidance to ...

Part 2a is designed to confirm the primary dose-of-interest with a target enrollment of approximately 30 patients at each of two dose levels: 400mg QD 5:2 and 300mg QD 5:2 (intermittent daily dosing ...

得到了较为稳定的酶活性。 我主要是来补充一个“失去了什么”的——失去了心脏的再生能力。 心肌梗死的预后问题是个困扰医生和病人很久的问题，这个事就是失去了心脏再生能力的结果，而这个结果就与恒温有关，甚至可以说是恒温的代价。

Bayer and Vividion Therapeutics to present latest research on their advancing oncology portfolio at AACR 2025 annual meeting: Berlin, Germany Wednesday, April 23, 2025, 10:00 Hrs ...

Background: Our previously research has validated the effect of circELMOD3 on HCC tumor inhibition. However, further investigations are warranted to investigate the prognostic significance of ...

Cdk2/Cyclin Inhibitory Peptide I 由 20 个氨基酸残基组成。其氨基酸序列中包含多个带正电荷的精氨酸（R）和赖氨酸（K）残基，这赋予了分子一定的阳离子特性，可能有助于与带负电荷的靶分子区域通过静电相互作用结合。分子中的酪氨酸（Y）、苯丙氨酸（F）等具有 ...

在细胞生物学研究中，为探究 DNA 复制与有丝分裂的联系，研究人员以细胞周期为主题开展研究。他们发现有丝分裂激酶的逐渐激活可确保 CDK1 依赖性转录，且激活时间影响有丝分裂进程。该研究揭示了细胞有丝分裂准备的调控机制，意义重大。

It also develops RLY-8161, an oncogene driver that belongs to the RAS family of signaling proteins for NRAS-mutated solid tumors; RLY-1013, an oral, potent, selective, bifunctional protein degrader of ...

阔然生物推出的一站式NGP检测方案可对乳腺癌的肿瘤微环境进行全面解析，检测方案可纳入P16INK4A、cyclin E1、RB、cyclin A、Geminin等指标深入研究CDK2抑制剂疗效的生物标志物。 P16INK4A与cyclin E1共表达定义CDK2抑制剂敏感亚群 研究背景： 在癌症治疗领域，靶向细胞 ...

Oncogene-Induced Senescence (OIS) is triggered by the activation of oncogenes such as RAS, BRAF, AKT, E2F1, and cyclin E, or by the inactivation of tumor suppressor genes including PTEN and NF1. This ...

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