Background: circHIPK3 role in cancer as oncogene or tumor suppressor is still debated, therefore, this study aimed to understand the dual role of this circRNA in different cancers. Furthermore, all ...

Figure 1 Role of IL-27 in monocyte. IL-27 (IL-27p28, Ebi3) binds to receptor IL-27rα and gp130 and activates downstream signaling including ERK, NF-κB, AP-1, and JAK2, and then regulates activation of ...

新闻稿指出，Camizestrant 是首个且唯一一个新一代口服 SERD 和完全 ER 降解，与广受认可的 CDK4/6 抑制剂联合使用可在一线治疗中带来益处。 值得一提 ...

Camizestrant combined with CDK4/6 inhibitors improved progression-free survival in HR+/HER2- advanced breast cancer with ESR1 mutations in the SERENA-6 trial. In the phase 3 SERENA-6 trial ...

近年来，细胞周期蛋白依赖性激酶 4/6（CDK4/6）抑制剂联合内分泌治疗已成为 HR+/HER2- 晚期乳腺癌的一线标准治疗。然而，耐药性的出现限制了其临床 ...

"In the amygdala, the gene Stat3 is involved in the regulation of blood pressure and possibly plays a role in blood pressure elevation in response to chronic stress. It might also be involved in ...

Paolo Tarantino, MD, PhD, medical oncologist and clinical fellow at Dana-Farber Cancer Institute, discusses elacestrant (Orserdu) as a well-tolerated treatment option for patients with hormone ...

历经十年沉淀，CDK4/6抑制剂这一细分市场在规模上已经成长为近130亿美元的黄金赛道。 历经十年沉淀，CDK4/6抑制剂这一细分 ...