Melanoma susceptibility genes CDKN2A and CDK4 play a role in the development of melanoma, especially among some familial melanoma kindreds. The functions of CDKN2A and CDK4 in melanoma development ...

Dr. Yoshida has recently identified CDK4/6 as a target for therapeutic intervention in melanoma. Therefore, Dr. Yoshida has utilized a CDK4/6 inhibitor (CDK4/6i) to suppress melanoma growth.

We determine how an altered epigenetic landscape contributes to the resistance to CDK4/6 inhibitor and develop the strategies that suppress the development of resistance. 2) Overcoming chemotherapy ...