Melanoma susceptibility genes CDKN2A and CDK4 play a role in the development of melanoma, especially among some familial melanoma kindreds. The functions of CDKN2A and CDK4 in melanoma development ...
Dr. Yoshida has recently identified CDK4/6 as a target for therapeutic intervention in melanoma. Therefore, Dr. Yoshida has utilized a CDK4/6 inhibitor (CDK4/6i) to suppress melanoma growth.
2) Overcoming chemotherapy resistance by a combination with immunotherapy in melanoma. Our preliminary data revealed that PD-1, an immune checkpoint protein, is involved in the resistance to one ...
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