为探究 CDK7 如何协调细胞周期与 RNA 聚合酶 II 转录，研究发现其通过调控核心转录因子网络实现，意义重大。 在生命的微观世界里，细胞的生长、分裂如同精密的时钟，有条不紊地进行着。而在这背后，有一个关键的 “指挥官”—— 细胞周期蛋白依赖性激酶 7 ...

Quantitative and Differential Analysis between Bupleurum chinense DC. and Bupleurum scorzonerifolium Willd. Using HPLC-MS and GC-MS Coupled with Multivariate Statistical Analysis. Comparative ...

作为我国首个抗衰中药的随机、双盲、安慰剂对照人体临床试验，该研究坐实八子胶囊成果的综合抗衰潜力，使其在海内外引起巨大反响。 对于健康 ...

Inflammation is a biological response to harmful stimuli, such as pathogens, damaged cells or irradiation. It is a protective attempt by the organism to remove injurious stimuli and to initiate ...

为解决肝细胞癌（HCC）早期诊断困难和治疗耐药问题，郑州大学第一附属医院的研究人员开展 BRD4 相关基因研究。他们构建四基因预后模型，发现联合抑制剂可增效。这为 HCC 诊疗提供新思路，强烈推荐科研读者阅读。 郑州大学第一附属医院（Department of ...

We emphasize, however, that the effects of CDK8/CDK19 on splicing are modest, especially compared with CDK7, a different transcription-associated kinase (Rimel et al. 2020). Under conditions of IFN ...

研究人员通过对小鼠进行研究后发现，阻断包括Brd4和IL-1β的巨噬细胞纤维化通路中的不同步骤或能帮助减缓患心脏病动物机体的心脏纤维化发生。

The company has also presented encouraging initial Phase 1 data for its CDK7 inhibitor, REC-617. Recursion also released OpenPhenom-S/16, a publicly available foundation model for microscopy data ...

The bromodomain-containing protein BRD4 has been thought to transmit epigenetic information across cell divisions by binding to both mitotic chromosomes and interphase chromatin. UV-released BRD4 ...