CU Boulder researchers have uncovered how the enzyme CDK7 drives cell proliferation by controlling a key group of transcription factors, and how inhibiting it can rapidly shut down this process across ...

Stephen has a science degree with a major in physics, an arts degree with majors in English Literature and History and Philosophy of Science and a Graduate Diploma in Science Communication.

Inflammation is a biological response to harmful stimuli, such as pathogens, damaged cells or irradiation. It is a protective attempt by the organism to remove injurious stimuli and to initiate ...

Head and neck cancer comprises a group of biologically similar cancers that start in the lip, oral cavity (mouth), nasal cavity (inside the nose), paranasal sinuses, pharynx and larynx. Most head ...

But when that process goes awry, leading to uncontrolled cell growth, cancer can emerge. New CU Boulder research, published in the journal Science Advances, offers unprecedented insight into how an ...

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However, CDK4/6 inhibitors have their limitations. Many tumors develop resistance by switching to alternative CDK pathways, pushing for the next-generation CDK inhibitors to target CDK2, CDK7, and ...

Breast cancer (BC) is a malignant tumor that has the highest morbidity and mortality rates in the female population, and its high tendency to metastasize is the main cause of poor clinical prognosis.

Exscientia’s current clinical-stage pipeline consists of CDK7 inhibitor GTAEXS-617, which is co-owned with GT Apeiron, Evotec-partnered A2A receptor antagonist EXS-21546, and BMS-partnered PKC ...