The Food and Drug Administration has approved the world’s first medicine based on CRISPR gene-editing technology, a ...

过去15年来，基因编辑技术CRISPR-Cas9的进步，使人们对特定基因在许多疾病中发挥的作用有了重要的新见解。但是到目前为止，这项允许科学家使用“引导”RNA来修改DNA序列并评估其效果的技术只能用单个引导RNA靶向、删除、替换或修改单个基因序列，并且同时 ...

CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

Learn about Brink Therapeutics as it raises $4 million to go beyond CRISPR with engineered recombinases in CAR T therapy.

Scientists and policymakers are meeting in Washington, DC December 1-3 to debate the use of CRISPR/Cas9, a tool that makes it possible to make changes to an organism's DNA almost as easily as ...

A new set of genes that contribute to Parkinson’s disease risk has been identified.

The medical promise of CRISPR gene editing can be seen most easily in current research on oral cancer, which affects more than 50,000 Americans every year. An increasing challenge in the treatment ...

In the Advanced Science study, researchers explain why tumors are so difficult to target using CRISPR. The replicative nature ...

Dire wolves, extinct for over 10,000 years, are back thanks to Colossal Biosciences. Using ancient DNA and CRISPR gene ...

为解决 CRISPR-Cas12a 在基因编辑中脱靶切割及 R 环形成机制不明的问题，研究人员开展了 Cas12a R 环形成动力学和力学的研究。结果发现其 R 环形成有多步中间态，受多种因素影响，相关模型揭示了其活性和特异性的机制，为基因编辑提供理论基础。 在生命科学的 ...