Furthermore, regulation of STK11 (the gene encoding LKB1) expression at the genetic level can also influence LKB1-AMPK pathway activity (96). These diverse regulatory mechanisms provide rich potential ...

本文通过对藏族和汉族全基因组测序，发现多个受选择区域，揭示 MCUR1 基因在高原适应（HAA）中调节红细胞生成的新机制。 研究背景 青藏高原平均海拔超 4000 米，氧气稀薄、气候寒冷，对人类生存构成巨大挑战。然而，藏族人却在这片土地上成功定居数千年 ...

二甲双胍是经典的降糖药物，临床应用已有60多年，且具有降糖之外的多种益处，更多治疗潜力还在不断展现中，素有“神药”之誉。这种源自天然草药山羊豆的药物，为何能拥有如此宽泛的功效？尽管目前为止二甲双胍的作用机制尚未完全阐明，但众多证据 ...

Mammalian AMP-activated protein kinase (AMPK) was discovered as a protein kinase that switches off lipid synthesis. The yeast orthologue, the SNF1 complex, was discovered in screens for mutations ...

Here, we show that Tda1, the yeast ortholog of human Nuak1, is a direct kinase for H3pT11 upon low glucose stress. Yeast AMP-activated protein kinase (AMPK) directly phosphorylates Tda1 to govern Tda1 ...

AMP-activated protein kinase (AMPK), a key metabolic regulator, plays an essential role in the maintenance of energy balance in response to stress. Tuberculosis (TB), primarily caused by the pathogen ...