Additionally, mesenchymal markers like Vimentin and α-SMA were also diminished, while epithelial markers such as E-cadherin, Occludin, and ZO-1 were elevated, suggesting a disrupted EMT process.

The study represents the first attempt to explore the role of T-cadherin in COVID-19 pathogenesis as well as its implications in pulmonary fibrosis and endothelial dysfunction. First, we revealed a ...

Beyond providing a proof of concept, our findings also provide new mechanistic insights into the functionality of ROCK inhibitors in VE cadherin–mediated cell–cell junctions, elucidating how they can ...

We show that cadherin-mediated cell–cell adhesion regulates differential cellular responses to compressive stress and is an important driver of unjamming in stressed monolayers. Importantly, ...

PRAGUE, Czech Republic and LONDON, UK I March 03, 2025 I SOTIO Biotech, a clinical-stage biopharmaceutical company owned by PPF Group, today presented the first preclinical data on SOT109, a novel ...

targeting cadherin-17 (CDH17). The data highlight SOT109's promising activity and tolerability profile across multiple disease models, reinforcing its potential to become a best-in-class ...

为探究可溶性 E - 钙粘蛋白（sE-cadherin）在 ALI/ARDS 中的作用，广州医科大学附属第一医院研究人员开展相关研究，发现 sE-cadherin 通过 VEGF/VEGFR2 通路促进肺炎症，为 ALI/ARDS 治疗提供新方向。 急性肺损伤（ALI）及其更严重的急性呼吸窘迫综合征（ARDS），就像潜伏在 ...

You'll be able to purchase pieces from the collection by heading over to Complex Shop, where you can sign up to get notified when pieces drop. “I feel lucky to be able to work alongside Complex ...

Through comparative transcriptome analysis, Professor Kai-Chien Yang's group identified the adherens junction protein N-Cadherin as a key regulator of CM proliferation and renewal. Its expression ...

However, distinct from its role in cell–cell adhesion, the repulsion process is independent of N-cadherin trans-homodimerisation and the associated adherens junction complex. Rather, the extracellular ...