Acquisition of invasive and metastatic capabilities is frequently associated with loss of cell–cell adhesion. One of the major constituents of the cell-adhesion complex in epithelial cells is E ...

Cadherins are integral transmembrane proteins that are involved in cell sorting, cell aggregation and tissue morphogenesis during embryogenesis, and postnatally, mediate cell-to-cell adhesion.

The whole P-cadherin/antibody/drug complex is then sent to a structure called the lysosome to be broken down.