It was reported that there were no significant changes in the level of cardiac cAMP or phosphodiesterase (PDE) that could be responsible for the inotropic effect of amrinone. The original observations ...

A library for solving differential equations using neural networks based on PyTorch, used by multiple research groups around the world, including at Harvard IACS.

Abstract: This letter explores the stabilization of a wide class of coupled dynamical systems, consisting of partial and ordinary differential equations with spatially varying coefficients. The main ...

For decades, studies of snake venoms focused on the venom-ome-specific toxins (VSTs). VSTs are dominant soluble proteins believed to contribute to the main venomous effects and emerged into gene ...

(8) Pentoxifylline is a non-specific PDE inhibitor, which can increase intracellular cAMP concentration and plays an anti-hepatic fibrosis role by inhibiting TNF-α production. (9) Attenuating ...

cAMP enhanced the acidification of endosomes for Fe(II) release to the LIP likely through RapGEF2. The effect of cAMP on Fe(II) and 5hmC was confirmed by adenylate cyclase activators, ...

Here we present original observations on the available components of the cAMP signaling pathway in the human placenta including PKA, PDE, and PP isoforms as well as AKAPs. We continue to discuss the ...