Elevated expression of caspase-3 and caspase-8 promotes apoptosis, while increased expression of caspase-1 and TNF-α amplifies the immune response. Additionally, activation of the JAK/STAT3) pathway ...

In conclusion, this study shows that S1pr3 contributes to PF by modulating macrophage M2 polarization through the PI3K/Akt-Stat3 signaling pathway. In addition, S1pr3 inhibitors were effective against ...

免疫组化分析（IHC）用于评估肺组织中 CD206、转化生长因子 β1（TGF-β1）等多种蛋白的表达水平。同时，研究人员还进行了血常规和血液化学检测，并收集患者居住区域的空气污染数据，评估其与生物标志物表达的关联。最后运用统计分析方法，明确各指标与 PF ...

研究人员针对结直肠癌预后和治疗难题，研究 STAT 家族，发现 STAT3 和 STAT5B 可作预后生物标志物及免疫治疗靶点。 结直肠癌研究新突破：STAT3 和 STAT5B 的关键作用 在全球范围内，结直肠癌的发病率和死亡率居高不下，严重威胁着人类的健康，成为全球健康的沉重 ...

1 Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan 2 Department of Functional Genomics and Immunological Diseases, Graduate School of Medicine ...