Particularly, whole-cell patch-clamp experiments would limit the target molecules to those acting externally, potentially overlooking molecules that act intracellularly. Additionally, our extraction ...

A significant challenge was to identify correlations between transcriptomic and cytological data to fully define each cytological cell type. This challenge was overcome by combining multiple ...

This work developed a new biochemical method that uncovered the function of a poorly characterized protein called calmin," said W. Mike Henne, Ph.D., Associate Professor of Cell Biology and ...

Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), ...

The metrics are designed mainly for tissue images assuming that (1) there are multiple channels, and (2) there are multiple cell types that are expected to differ in their expression values for the ...

Reference: Haoran Chen and Robert F. Murphy (2023) 3DCellComposer - A Versatile Pipeline Utilizing 2D Cell Segmentation Methods for 3D Cell Segmentation. Under review. Changes in V1.3: Options added ...

Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Xiamen 361005, P.R. China State Key Laboratory of Physical Chemistry of Solid Surfaces, College of ...

Despite of the fact that integration of single-cell multi-modal data has been extensively explored in existing studies, computational methods specifically developed to integrate copy number and point ...

Scientists have developed a novel method to efficiently grow motor neurons from skin cells, which may serve as a platform for creating cell therapies to treat diseases like amyotrophic lateral ...