The cGAS-STING signaling pathway, a key element of the innate immune response, has risen as a promising avenue to amplify this therapeutic approach. Unraveling the pathway's role in immune system ...

The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME). The activation of cGAS-STING promotes the release and presentation of cancer antigens ...

An artist's impression of cGAS-STING pathway response model for micronucleus. Before, cGAS's accumulation in micronuclei was considered to be an indicator of cGAS activation. Now, it was found ...

Triggered by an enzyme called DNA protein kinase (DNA-PK), the newly found pathway is independent of the cGAS-STING pathway—until now considered the main regulator of mammalian innate immune responses ...

this finding solidified its place as the elusive cytosolic DNA sensor to complete the cGAS-cGAMP-STING pathway. “It was quite a surprise that this sensor turned out to be an enzyme,” said Chen.

A conserved molecular pathway controlled by the proteins cGAS, STING and IRF3 can detect DNA outside of these compartments, ...

In addition, research is focused on protein-RNA complexes mediating the piRNA pathway (with Julius Brennecke, IMBA-Austria), on identification and characterization of small molecule inhibitors ...