其实从分类来说，mtDNA此前更多是被划分到细胞释放的损伤相关分子模式（DAMPs）之中，全身各处的免疫细胞可通过cGAS等感受器感知到游离mtDNA，进而激活与 创伤 、炎症性疾病乃至癌症对应的免疫应答 [2]；2023年登上《自然》的一项研究 ...

神经性疼痛治疗困难，研究人员开展 CMPK2 在其中作用的研究。发现 CMPK2 通过促进小胶质细胞糖酵解、增加乳酸化使 cGAS-STING 通路失活，加剧疼痛。该研究为治疗神经性疼痛提供新靶点，意义重大。

使mtDNA激活cGAS-STING-NF-κB信号，增强PMN-MDSCs的免疫抑制性。只能说，老而不死的癌细胞也太阴险了，针对性阻断mtDNA释放的关键通道，才有望逆转免疫 ...

为探究 STX12 缺乏的病理生理改变及致死机制，研究人员构建 Stx12 基因敲除小鼠和敲低斑马鱼模型开展研究。结果发现 STX12 缺失导致线粒体损伤、mtDNA 释放，激活 cGAS-STING 通路和炎症反应，这为揭示相关疾病机制提供了新视角。

An artist's impression of cGAS-STING pathway response model for micronucleus. Before, cGAS's accumulation in micronuclei was considered to be an indicator of cGAS activation. Now, it was found ...

The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME). The activation of cGAS-STING promotes the release and presentation of cancer antigens ...

The cGAS-STING signaling pathway, a key element of the innate immune response, has risen as a promising avenue to amplify this therapeutic approach. Unraveling the pathway's role in immune system ...

Triggered by an enzyme called DNA protein kinase (DNA-PK), the newly found pathway is independent of the cGAS-STING pathway—until now considered the main regulator of mammalian innate immune responses ...

Because cGAS was the only candidate that produced cGAMP activity, this finding solidified its place as the elusive cytosolic DNA sensor to complete the cGAS-cGAMP-STING pathway. “It was quite a ...

"With the discovery and mapping of the cGAS-STING signaling pathway, the award winners have opened up completely new approaches to drug research," explains Thomas Boehm, Chairman of Paul Ehrlich ...