为对比扎韦格潘（zavegepant）与口服 CGRP 受体拮抗剂治疗偏头痛的效果，研究发现前者起效快但长期优势不明显。 偏头痛，这种让人痛苦不堪的神经系统疾病，如同一个隐藏在暗处的 “小恶魔”，常常突然发起攻击。它以单侧或双侧搏动性头痛为典型特征 ...

CGRP-1, a downstream target of TRPM8, displayed the same trend across different groups ... MAPK is involved in various biological processes, including cell growth, differentiation, and apoptosis.

为探究 CGRP 亚型在溃疡性结肠炎（UC）中的作用，研究人员用基因敲除小鼠实验，发现 CGRP β 可抑制 UC，为治疗提供新思路。 溃疡性结肠炎（Ulcerative Colitis，UC）是一种令人困扰的肠道疾病，患者常常遭受腹泻、便血、腹痛等症状的折磨，生活质量严重下降。

Some of these dead cells will have died by a highly controlled process known as apoptosis. These so-called apoptotic cells display signals on their surface that nearby healthy cells recognize. This ...

In conclusion, TRPA1 plays an pro-inflammatory role in inflammatory diseases by the release of IL-1, TNF-α, and IL-6 while CGRP promotes the inflammatory response and local ... reducing the release of ...

Migraine involves the central nervous system, trigeminal nerves and meninges. Recent advances have shown that targeting calcitonin gene-related peptide (CGRP) through either antibodies or small ...

Parabrachial CGRP neurons receive diverse threat-related signals and contribute to multiple phases of adaptive threat responses in mice, with their inactivation attenuating both unconditioned ...