The full–length chimeric molecules constructed from plasma–derived HIV–1 RNA and proviral DNA–derived LTRs were tested for infectivity by transfection into human dermal fibroblast cells ...

此次研究由未提及具体单位的研究人员开展，他们运用改进的嵌合增强型紫外交联免疫沉淀（chimeric eCLIP）技术，对 snoRNA 与靶 RNA 之间的相互作用进行了深度剖析。研究成果发表在《Genome Biology》期刊上。 在研究过程中，研究人员用到了多种关键技术方法。

他们对 CICs 和分化的肿瘤细胞系进行了多组学分析，包括 DNA 甲基化分析、总 RNA 测序和微小 RNA（MicroRNA，miRNA）表达谱分析 ，以此来全面了解两种细胞在基因层面的差异。同时，进行功能免疫学实验，比如混合淋巴细胞肿瘤细胞培养 ...

Chimeric RNA landscape in the Chinese population and the role of SFT2D2-TBX19 in prostate cancer progression. Risk stratification using the Decipher 22-gene genomic classifier (GC) and digital ...

随着生物信息学和人工智能的不断进步，越来越多的创新工具进入了科研人员的视野，推动了科学研究的快速发展。在这些工具中，AlphaFold 3无疑是近年来最为引人注目的一个。作为DeepMind团队推出的最新版本，AlphaFold ...

Gene silencing is a negative feedback mechanism that regulates gene expression to define cell fate and also regulates metabolism and gene expression throughout the life of an organism. In plants, gene ...

Moreover, the review discusses several alternative therapies, including RNA-based treatments, aptamers, peptide-based therapies, phage therapy, and probiotics, discussing their applications, ...

Her group has developed algorithms to predict miRNA genes and miRNA targets, and has worked on the development of the CLIP method (cross-linking and immunoprecipitation) for mapping the binding sites ...