Chimeric RNAs and the proteins translated from them often have a causal role in tumorigenesis. They are also occasionally found at low levels in healthy cells. These phenomena were previously ...

此次研究由未提及具体单位的研究人员开展，他们运用改进的嵌合增强型紫外交联免疫沉淀（chimeric eCLIP）技术，对 snoRNA 与靶 RNA 之间的相互作用进行了深度剖析。研究成果发表在《Genome Biology》期刊上。 在研究过程中，研究人员用到了多种关键技术方法。

他们对 CICs 和分化的肿瘤细胞系进行了多组学分析，包括 DNA 甲基化分析、总 RNA 测序和微小 RNA（MicroRNA，miRNA）表达谱分析 ，以此来全面了解两种细胞在基因层面的差异。同时，进行功能免疫学实验，比如混合淋巴细胞肿瘤细胞培养 ...

The full–length chimeric molecules constructed from plasma–derived HIV–1 RNA and proviral DNA–derived LTRs were tested for infectivity by transfection into human dermal fibroblast cells ...

Initially, miRNAs are transcribed by RNA polymerase II as long primary transcripts called pri-miRNAs. These pri-miRNAs are then processed by the Drosha-DGCR8 complex into shorter hairpin-shaped ...

Molecules that combine elements of RNA and DNA, so-called chimeric molecules, may have been an important step in the emergence of life on Earth from the primordial soup that existed billions of years ...

The small molecules used to control the RNA switch can be any cellular biomolecule, including metabolites, siRNA, miRNA, or proteins. In fact ... Transcription-induced RNA mutations include chimeric ...

The ChiTaRS 8.0 database contains over 47,000 RNA transcripts and more than 100,000 chimeric sequences identified in humans. The database integrates with a "digital hospital" model, which allows ...