Mitosis orchestrates eukaryotic cell division, maintaining genetic fidelity and playing a key role in development, tissue homeostasis, and cancer progression.

We do not understand the nature of the factors that control the regional distribution of recombination along chromosomes, the mechanisms that control chromatid compaction and interference nor the ...

Women are born with two X chromosomes and inherit one from each parent. But in every cell of their body, just one X chromosome is needed—so the other is randomly inactivated. Some cells use only ...

A key target of the APC is securin, the destruction of which initiates chromosome segregation by unleashing the protease separase, which destroys sister-chromatid cohesion. The APC also ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Chromosome segregation relies on kinetochores ...