When skin is cut or damaged, tiny cell fragments circulating in the blood, called platelets, arrive at the injury and spread out to stop the blood from leaking out. Once enough layers of platelets ...

Platelet spreading and clot contraction are controlled by different pathways. This discovery leads to safer treatments for ...

Until recently, researchers believed that platelet spreading and clot contraction were controlled by the same pathway. However a recent study from Thomas Jefferson University researchers challenges ...

Clotting is initiated by two processes or pathways - a slower but larger intrinsic pathway (contact activation pathway) or a very rapid extrinsic pathway (tissue factor pathway) - which lead to ...

Factor XI Inhibitors are the alternative to DOACs, which are highly effective at preventing strokes. However, their bleeding risks often limit their use, especially in high-risk patients.

Sanofi has received FDA approval for Qfitlia, its innovative hemophilia therapy that represents the first antithrombin-lowering treatment for hemophilia A or B patients with or without inhibitors ...

When injured, endothelial cells permit granulocytes and plasma constituents to enter inflamed tissue, which may lead to organ damage. Endothelial cell inflammation causes vasodilation through the ...

By stopping the clotting factor, you stop the protein that ... “Aspirin, or other drugs that could target this pathway, have the potential to be less expensive than antibody-based therapies ...