Why do medications that are supposed to help patients with chronic inflammatory diseases sometimes lead to blood clots?

Colchicine, doxorubicin (adriamycin), mitoxantrone, and verapamil were purchased from Sigma Aldrich Trading Co. (Shanghai, China). All of the drugs were dissolved in 100% DMSO to produce a 10 mM stock ...

Objective: Gastric cancer is one of the most common malignant tumors. Bruceine D (BD) is one of the extracts of Brucea javanica. In recent years, it has been reported that BD has anti-tumor activity ...

We show that AhR activation in macrophages causes a block to HIV-1 and HSV-1 replication. We find that AhR activation transcriptionally represses cyclin-dependent kinase (CDK)1/2 and their associated ...