为探究腹侧被盖区（VTA）中 D1 和 D2 样多巴胺受体对束缚应激（RS）影响痛觉阈值的调节作用，研究人员对大鼠开展实验。结果显示 RS 可增强急性疼痛模型的抗伤害感受行为，阻断 VTA 多巴胺受体能削弱该反应。此研究为疼痛管理提供新方向。 在疼痛的世界里 ...

编者按：2025年美国临床肿瘤学会年会（ASCO）将于美国东部时间（GMT-5）5月30日至6月3日在芝加哥召开。本次会议聚焦肿瘤治疗前沿，将呈现化疗、内分泌治疗、免疫治疗、靶向治疗及精准医学的最新进展。日前，官网已经公布各项研究摘要，本文特将消化领 ...

Cyclin D1–CDK4/6 phosphorylates GTSE1 in cancer cells, preventing its degradation and sustaining high levels across the cell cycle, which enhances proliferation and correlates with poor prognosis.

Our data showed an atypical expression profile of dopamine receptor D2 (DRD2) in various cell lines of SCLC belonging to NE, non-neuroendocrine, brain metastatic (BrM), and chemotherapy-resistant ...

A new drug has shown promise in combating Parkinson’s disease while minimizing unwanted side effects.

Tavapadon’s mechanism is thought to improve motor control via the D1/D5 receptors but avoids overstimulation of the D2/D3 receptors thought to cause side effects. It is also in two phase 3 ...

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Levodopa — which is converted into dopamine in the brain and targets the D2/D3/D4 dopamine receptors ... mimicking dopamine and targeting the D1/D5 receptors, was found to have the same ...

Motivation is the driving force that elicits a certain behaviour from an organism in order to satisfy the drive or seek a particular goal. Motivation can be induced by physiological drives such as ...

At the same time it also avoids stimulating similar receptors, such as the dopamine D2 receptor, that can lead to unwanted side effects. This type of selective dual targeting is a major challenge ...