Cyclin D1–CDK4/6 phosphorylates GTSE1 in cancer cells, preventing its degradation and sustaining high levels across the cell cycle, which enhances proliferation and correlates with poor prognosis.

Listening to our favorite music activates the same parts of the brain as food and sex, reveals new research. The study showed ...

A new pill, tavapadon, has shown potential in easing Parkinson’s symptoms while limiting side effects. In patients taking at ...

The current study shows that the dopaminergic supply in the affected brain areas is altered. In addition, an increased ...

Here, the authors report a modular click ligand-directed approach to covalently attach fluorescent dyes to endogenous dopamine D1 receptors in live cells. CXCR3 and CXCR7 are chemokine receptors ...

The U.S. Food and Drug Administration has approved a self-injection version of Vyvgart Hytrulo (efgartigimod alfa and ...

The highly selective partial agonist at D1 and D5 receptors significantly improves motor function in patients recently ...

Not everyone with ADHD responds to stimulants like Ritalin, which increase dopamine levels in the brain. Now, new research ...

The study specifically examines two types of GPCRs expressed on astrocytes: dopamine D1 receptors (D1R) and metabotropic glutamate receptor 5 (mGLUR5). These receptors respond to various ligands, ...

Although many ecDNA-encoded oncogenes and their protein products, such as epidermal growth factor receptor (EGFR) and fibroblast growth factor receptor 1 (FGFR1), are validated drug targets for ...

Autoimmune generalized myasthenia gravis is a disease that manifests with fluctuating muscle weakness. Inebilizumab is a monoclonal antibody that depletes CD19+ B cells, which are central to ...