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靶向 ApoE4 的小分子 SirT1 增强剂 DDL-218:阿尔茨海默病治疗新希望
阿尔茨海默病(AD)影响众多老年人,ApoE4 是散发性 AD 主要风险因素,其降低 Sirtuin 1(SirT1)表达。研究人员发现小分子 DDL-218 可增强 SirT1,改善 AD 模型小鼠记忆。这为 AD 治疗提供新方向,有望补充现有疗法。 阿尔茨海默病,这个如同 “大脑橡皮擦” 的恶魔 ...
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