在 DNA 损伤响应（DDR）机制尚未完全明晰的背景下，研究人员开展了关于组蛋白乙酰转移酶 CBP 在 DNA 损伤后通过 ATM 调节 DDR 作用的研究。结果发现 CBP 参与 ATM 激活和 DNA 双链断裂修复，这为癌症治疗中调控细胞对 DNA 损伤剂的反应提供了潜在靶点。

This study provides valuable findings on the role of site-specific DNA methylation changes during spermatogenesis and their contribution to paternal epigenetic inheritance. The study proposes that ...

Kundu and James Clement discovered that the brain represses the acetylation of DNA-associated proteins, histones, or proteins that give chromosomes structural support in mice with a mutated syngap ...

Single-cell imaging and mass spectrometry data reveal adenosine in the DNA of mammalian cells can be methylated by METTL3 to form N6-methyladenosine in response to DNA damage.

Historically, therapies for ASD and ID have primarily targeted managing symptoms, such as behavioral issues or communication ...