The team then investigated its history using bioinformatical analysis to understand if its ancestors were RNA or DNA methyltransferases ... be used to develop new tools to investigate RNA ...

That is a key feature that has made Cas9 such a powerful tool. "Being RNA-guided makes it relatively easy to reprogram, ...

With the long-term goal of creating living cells from non-living components, scientists in the field of synthetic biology work with RNA origami. This tool uses the multifunctionality of the natural ...

So, the team at HHMI's Janelia Research Campus decided to build their own tool. The result is an innovative new technique that uses a novel DNA barcode system to track hundreds of RNA and protein ...

Learn about our Editorial Policies. At first glance, it may seem counterintuitive to edit a transient molecule like RNA when tools exist for targeting the root of the problem: the DNA. However, DNA ...

the Cas9 protein hooks up with the guide RNA and then moves along the strands of DNA until it finds and binds to a 20-DNA-letter long sequence that matches part of the guide RNA sequence.

In the microscopic world of bacteria, gene transfer is a powerful mechanism that can alter cellular function, drive antibiotic resistance and even shape entire ecosystems. Now an interdisciplinary ...

Riboglow, a collaboration between the Palmer and Batey labs in the Department of Biochemistry at CU Boulder, is a new take on these RNA-imaging tools based on naturally occurring RNA sequences, called ...

giving full transcriptome coverage and single-cell resolution in spatial RNA-sequencing." The new computational tool, Spot imager with pseudo single-cell resolution histology (Spotiphy), employs a ...