Epstein-Barr virus (EBV), a member of the herpesvirus family, is a highly common human pathogen that can remain latent in B lymphocytes after the primary infection. Although this latent state is ...

综合来看，这项研究意义非凡。研究人员通过 CRISPR/Cas 技术实现了高效的基因编辑，获得的 T 细胞既具有强大的靶向特异性，又对糖皮质激素具有抗性。这不仅为治疗移植后 EBV 激活或 EBV 相关疾病提供了新的治疗选择，也为 GMP 兼容的 CRISPR/Cas 工程生成抗糖皮质激素的 CAR-T 细胞产品奠定了基础。不过，目前该研究仍处于前期阶段，这种一体化的 gp350-CAR GR ...

EBV infects 95% of people and doesn’t usually ... as well as an antigen derived from gp350. Most earlier vaccine attempts have targeted gp350 alone. In animal studies, a similar vaccine ...