他们利用 CRISPR/Cas 介导的一体化方法，在符合药品生产质量管理规范（Good Manufacturing Practice，GMP）的平台上，将抗 EBV（gp350）的嵌合抗原受体（Chimeric Antigen Receptor，CAR）插入 T 细胞受体（T-cell receptor，TRAC）位点，同时敲除糖皮质激素受体（Glucocorticoid Receptor ...

EBV infects 95% of people and doesn’t usually ... as well as an antigen derived from gp350. Most earlier vaccine attempts have targeted gp350 alone. In animal studies, a similar vaccine ...

Epstein-Barr virus (EBV) exacerbates ulcerative colitis (UC) by inducing macrophage pyroptosis through enhanced glycolysis, worsening colonic inflammation and disrupting the intestinal barrier.

Epstein-Barr virus infection induces the upregulation of glycolysis in intestinal macrophages, which subsequently activates Gasdermin D, NLRP3, interleukin-1β, and interleukin-18 in macrophages ...

While its exact causes remain elusive, mounting evidence suggests that viral infections, particularly Epstein-Barr virus (EBV), may worsen disease severity. Elevated EBV DNA and RNA levels have ...

During a median follow-up of 6 to 8 years, MS occurred at a rate of 2.25 per 10,000 person-years among individuals with EBV-positive IM. Patients with a history of Epstein-Barr virus (EBV)-positive ...