Here I discuss recent advances in the study of endoplasmic reticulum stress as one mechanism ... but it gradually compromises macrophage function, driving the cells to stress, inflammation and ...

A protein's function directly depends on its folded ... in the sarcoplasmic reticulum — a specialized type of endoplasmic reticulum found in muscle cells. Since calcium is essential for muscle ...

The peripheral endoplasmic reticulum (ER) forms a continuous ... how the unique structure of the ER arises and supports its function is critical to developing a mechanistic understanding of ...

In biology textbooks, the endoplasmic reticulum is often portrayed as a distinct, compact organelle near the nucleus, and is ...

New research, published recently in Proceedings of the National Academy of Sciences, uncovers the unique dynamics governing ...

In biology textbooks, the endoplasmic reticulum is often portrayed as a distinct, compact organelle near the nucleus, and is ...

Researchers from Stanford University and LMU have uncovered how cells renew their endoplasmic reticulum’s protein factories.

The Jokitalo group studies structure-function interplay of organelles in mammalian cells. Our main model organelle is the endoplasmic reticulum. We employ a wide range of basic biological techniques ...

Transient Ca 2+ fluctuations on the surface of the endoplasmic reticulum (ER) can induce liquid-liquid phase separation (LLPS) of the autophagy initiation complex FIP200, forming FIP200 puncta and ...

Our research group is investigating the signalling and biological functions of GDNF neurotrophic family ligands and endoplasmic reticulum located CDNF/MANF protein families, both within and outside of ...