Oxygenases have long been thought to require a cofactor for catalysis. The structure of a vancomycin biosynthetic enzyme in complex with a substrate analog, and with molecular oxygen bound in its ...

These cofactors, or coenzymes, provide additional functionality that extends considerably the scope of enzyme-catalyzed reactions. Some cofactors (including the iron-porphyrin prosthetic groups of ...

The Stull lab primarily focuses on the class of enzymes that use riboflavin-derived cofactors (flavin-dependent enzymes), which catalyze a wide array of chemical transformations that are crucial for ...