Background Fibrolamellar carcinoma (FLC), a rare and fatal liver cancer lacking effective drug therapy, is driven by the DNAJ ...

Sclerosteosis is a rare genetic disorder that causes excessive bone growth, leading to life-altering complications, including hearing loss and facial paralysis.

Figure 1. Schematic of RAS and site of action of ACE inhibitors and ARBs. Unlike ARBs, ACE (kininase II) inhibitors inhibit bradykinin breakdown. Augmentation of bradykinin may have actions including ...

In using nojirimycin derivatives as glycosidase inhibitors, a large dose of the compounds is required to secure an effective endoplasmic reticulum lumenal concentration to eliminate the enzyme ...

1. ACE Inhibitors and ARBs Angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) are classes of drugs commonly prescribed for blood pressure and heart conditions.

Their dysregulation has been implicated in numerous diseases, particularly cancer. This is where kinase inhibitors come into play. Kinases have become one of the most extensively targeted enzymes in ...

All experiments with glycyl radical enzymes or activator enzymes were performed in a VAC Atmospheres glovebox ... for kinetic characterization or EPR analysis and NO inhibition, respectively. The ...

Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria sp8, 09042 Monserrato, Cagliari, Italy ...

He extracted two components from beetle abdomens, naming the substrate luciferine and the enzyme responsible for the reaction luciferase. 2 Not all bioluminescent marine organism systems can be used ...

Eligible studies had to meet the following inclusion criteria: 1) randomized controlled trials, quasi-randomized controlled trials or cross-over trials; 2) Study participants were adult patients; 3) ...

Table 1. Current therapeutic approaches to BC subtypes (adapted from Waks and Winer, 2019). Synthesis of compound 3, [(4-hydroxy-methyl)imidazolyl-1H-gold(I)-(2-benzoic-diphenylphosphane acid)] 50 ...