Epithelial NF-κB preserves the integrity of the gut epithelial barrier and coordinates the antimicrobial actions of the innate and adaptive immune systems. Deficiency in or hyperactivation of ...

As the body’s first line of defense against microbial intruders, epithelial cells are known for their ability to form tight physical and chemical barriers in tissues. But just how they maintain these ...

A significant discovery has identified a missing "gatekeeper" protein as the root cause of dry mouth in Sjögren's syndrome — a finding that could change the way the disease is treated.

The CRB1 gene encodes a transmembrane protein crucial for maintaining the integrity of epithelial barriers in both the retina and the colon. In the retina, CRB1 plays a vital role in the structure ...

Airway epithelial cells act as a physical barrier against environmental toxins and injury, and modulate inflammation and the immune response. As such, maintenance of their integrity is critical.

"By reinforcing the gut's protective barrier, we might prevent bacteria from invading the epithelial cells that line the intestine, which could halt both the onset and progression of the disease ...