该论文全面系统地总结了GSDMD的蛋白翻译后修饰（PTM）在细胞焦亡中扮演的各种角色，并探讨了其在免疫反应和炎症相关疾病中的潜在治疗意义。 综述还揭示了内源代谢物对GSDMD的直接调控机制。例如，富马酸通过琥珀化修饰GSDMD的关键半胱氨酸位点，阻断其与半 ...

This modulation alters the expression of the key structural region of GSDMD-N in cell pyroptosis, thereby effectively improving MI-induced cardiac hypertrophy and fibrosis (Zhang et al., 2022).

1 First School of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China 2 Department of Rehabilitation Medicine, Linyi People’s Hospital, Linyi, China Alzheimer’s ...