3.5 Validation of PANoptosis and epithelial cellular responses in human CD samples In surgically resected intestinal specimens from patients with CD, IHC revealed that the expression of apoptosis ...

In macrophages, GSDMD mutants lacking C192 were unable to efficiently form membrane pores or ... Cytokines such as interleukin-6 (IL-6) and TNF-α, released during pyroptosis, have been implicated in ...

Get Instant Summarized Text (Gist) Epithelial cells, previously thought to be silent, have been found to communicate using slow electrical signals, similar to nerve impulses but 1,000 times slower ...

Atherosclerosis is a chronic inflammatory condition and a known risk for the development of cardiovascular diseases. In animal models of atherosclerosis, macrophage pyroptosis is linked to the ...

该论文全面系统地总结了GSDMD的蛋白翻译后修饰（PTM）在细胞焦亡中扮演的各种角色，并探讨了其在免疫反应和炎症相关疾病中的潜在治疗意义。 综述还揭示了内源代谢物对GSDMD的直接调控机制。例如，富马酸通过琥珀化修饰GSDMD的关键半胱氨酸位点，阻断其与半 ...

Slow, silent 'scream' of epithelial cells detected for first time Date: March 17, 2025 Source: University of Massachusetts Amherst Summary: It has long been thought that only nerve and heart cells ...

为探究 Gasdermin D（GSDMD）激活机制，研究人员发现 GD-N T 泛素化调控其膜定位和激活，或为相关疾病治疗提供新靶点。 在细胞的世界里，有一种特殊的死亡方式 —— 细胞焦亡（pyroptosis），它就像细胞内部的一场 “火山爆发”。细胞焦亡时，细胞膜会形成小孔 ...

1Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union ...