为探究 Calpain-1 在细胞焦亡中的作用及开发检测工具，研究人员利用 HyCoSuL 方法设计了 Calpain-1 特异性工具，发现其可与焦亡标记物共定位并能直接切割 GSDMD，为解析蛋白酶在细胞死亡中的作用提供了平台。 钙蛋白酶 - 1（Calpain-1）是一种依赖钙的半胱氨酸蛋白酶 ...

Moreover, pyroptosis-related proteins (Caspase-1, IL-1β, GSDMD) were significantly reduced after physcion treatment. Interestingly, the diversity of intestinal bacteria and the abundance in physcion ...

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union ...

In macrophages, GSDMD mutants lacking C192 were unable to efficiently form membrane pores or ... Cytokines such as interleukin-6 (IL-6) and TNF-α, released during pyroptosis, have been implicated in ...

Atherosclerosis is a chronic inflammatory condition and a known risk for the development of cardiovascular diseases. In animal models of atherosclerosis, macrophage pyroptosis is linked to the ...

为探究 Gasdermin D（GSDMD）激活机制，研究人员发现 GD-N T 泛素化调控其膜定位和激活，或为相关疾病治疗提供新靶点。 在细胞的世界里，有一种特殊的死亡方式 —— 细胞焦亡（pyroptosis），它就像细胞内部的一场 “火山爆发”。细胞焦亡时，细胞膜会形成小孔 ...

"Epithelial cells do things that no one has ever thought to look for," says Granick. "When injured, they 'scream' to their neighbors, slowly, persistently and over surprising distances. It's like ...

Slow, silent 'scream' of epithelial cells detected for first time Date: March 17, 2025 Source: University of Massachusetts Amherst Summary: It has long been thought that only nerve and heart cells ...