Boosting MTMR7 production reversed signs of pulmonary arterial hypertension in a mouse model of PAH and may serve as a ...

p-extracellular signal-related kinase (ERK), t-ERK, p-p38, t-p38, p-c-Jun N-terminal kinases (JNK), t-JNK, p-Signal transducer and activator of transcription 3 (stat3), t-stat3 (Cell Signalling ...

We thank Professor John L. Rubenstein for his comments, suggestions, and edits. We are grateful to Professor Hua Han for sharing the Rbpj floxed mice, and Professor Jean M. Hebert for sharing ...

"In the amygdala, the gene Stat3 is involved in the regulation of blood pressure and possibly plays a role in blood pressure elevation in response to chronic stress. It might also be involved in ...

Periostin-deficient MDSCs displayed reduced activation of ERK, AKT and STAT3 and periostin deficiency decreased the immunosuppressive functions of MDSCs during tumor progression. Moreover, lysyl ...

It is generally accepted that IL6-mediated STAT3 signaling in hepatocytes, mediated via glycoprotein 130 (gp130; IL6ST), is beneficial and that the synthetic IL6:IL6ST fusion protein (HyperIL6) ...

Long-lasting long-term potentiation (L-LTP) is a cellular mechanism of learning and memory storage. Studies have demonstrated a requirement for extracellular signal-regulated kinase (ERK) activation ...

The two RET fusion genes described here leading to the aberrant activation of RET, are able to transform hematopoietic cells and skew the hematopoietic differentiation program towards the ...