we identified dynamic changes in novel subsets of fibroblasts during morphogenesis and resolved a putative differentiation hierarchy emanating from CD34 hi mesenchymal progenitor cells. Perturbation ...

This is a useful report of a spatially-extended model to study the complex interactions between immune cells, fibroblasts, and cancer cells, providing insights into how fibroblast activation can ...

NASDAQ:FBLG Hello and welcome to Virtual Investor Conferences. On behalf of the Life Sciences Investor Forum and our co-host, Zacks Small Cap Research, we're very pleased you joined us for our ...

In this study, we apply single-cell sequencing to investigate the role of the GEM gene in SLE. GEM, a GTPase involved in cellular processes such as fibroblast differentiation, has been implicated in ...

Pigment epithelium-derived factor (PEDF), a major antiangiogenic factor, is abundantly secreted by SSc fibroblasts. Here, we investigated the effect of TGF-β and Cav-1 on PEDF expression and the role ...

To determine whether Piezo2 signaling is required for stiffness-driven myofibroblast differentiation, the team cultured human lung fibroblasts on substrates of increasing stiffness with or without ...

This review discusses the diversity and heterogeneity of fibroblasts in secondary lymphoid organs such as lymph nodes, spleen, and Peyer’s patches, and their contributions to a range of pathological ...

Concept: Epithelial JAG1–NOTCH1 signaling promotes the transformation of normal fibroblasts into CAFs. Impact: Assessing epithelial differentiation and stromal-immune alterations may help track SCC ...

Artificial intelligence company OpenAI has announced a fivefold increase in the maximum bug bounty rewards for "exceptional and differentiated" critical security vulnerabilities from $20,000 to $ ...

“When we use embryonic stem cells, they undergo the whole process of programmed cell differentiation as it happens during embryogenesis,” said study author Shyam Sharan, a cancer geneticist at the ...