Cysts, fibrosis, and tubular degeneration form the typical triad of pathologies leading to the gradual decline in kidney ...

Major discrepancies are seen with the use of noninvasive tests compared with liver biopsy in a posttransplant setting.

A comprehensive proteomic map of liver fibrosis progression and healing in two mouse models identifies etiology-specific extracellular matrix components, laying the foundation for targeted ...

In late-stage DAD, the researchers saw an increase of markers associated with lung fibrosis—a lung pathology that causes scarring and stiffness in lung tissue, making it difficult to breathe.

More information: Margaret A.T. Freeberg et al, Piezo2 Is a Key Mechanoreceptor in Lung Fibrosis that Drives Myofibroblast Differentiation, The American Journal of Pathology (2025). DOI ...

Piezo2 is increased in idiopathic pulmonary fibrosis (IPF). Immunohistochemistry of nonfibrotic (left) and IPF (right) lung tissue demonstrating that Piezo2 (brown staining) is strongly present in ...

Protein clustering mechanism on the cell membrane presents a new therapeutic target for cystic fibrosis. A new study from The Hospital for Sick Children (SickKids) reveals the process underlying ...

A key factor in the pathology of MASH is the disruption of ... including excessive lipid accumulation, fibrosis, and heightened ER stress, mirroring MASH. Additionally, they saw a rise in ...

Key findings include: AI-assisted digital pathology 49.2% (p=0.02 vs placebo) of 600 mg treated patients achieving a ≥1-stage improvement in fibrosis versus 25.7% of placebo treated patients as ...